Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.Interactive NFKappa Pathway
Click on any interested proteinor antibody ID in the NFKappa pathway to list relevant products below.Our team of experts will customize experimental protocol for your research and diagnostics needs.
Nuclear factor-kB (NF-kB)/Rel proteins control genes involved in inflammation, innate and adaptive immunity, B-cell development inflammation, and stress responses. In the canonical NF-kB pathway, IkB proteins bind and inhibit NF-kB/Rel proteins. A host of receptors activate an IKK complex that phosphorylates IkB proteins, triggering ubiquitination and proteasomal degradation, liberating NF-kB/Rel complexes which ultimately migrate to the nucleus to upregulate target gene expression. In the noncanonical pathway, specific receptor signaling activates kinase NIK, which activates IKKa complexes that phosphorylate residues in NF-kB2 p100. This process promotes ubiquitination and proteasomal cleavage to NF-kB2 p52. NF-kB p52/RelB complexes move to the nucleus to induce target gene expression.
