Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.CREB Pathway
Click on any interested protein or antibody ID in the CREB Transcription pathway to list relevant products below.
Extracellular stimuli summon changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate nuclear transcription factors. Transcription factor CREB1 (cyclic AMP (cAMP) responsive element binding protein 1) activates transcription of the target genes in response to a wide array of stimuli, including peptide hormones, growth factors, and neuronal activity. CREB1 is essential to a variety of cellular processes, including proliferation, differentiation, and adaptive responses. CREB proteins are critical for learning and memory and contribute to neuronal adaptation to drugs of abuse and hormonal control of metabolic processes, including regulation of gluconeogenesis by hormones glucagon and insulin.
