SOX2 Antibody
Purified Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, ICC, E |
---|---|
Primary Accession | P48432 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 10F10 |
Isotype | IgG1 |
Calculated MW | 34kDa |
Description | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. |
Immunogen | Purified recombinant fragment of human SOX2 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Gene ID | 20674 |
---|---|
Other Names | Transcription factor SOX-2, Sox2, Sox-2 |
Dilution | WB~~1/500 - 1/2000 IF~~1/200 - 1/1000 IHC~~1/500 - 1/2000 |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SOX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Sox2 |
---|---|
Synonyms | Sox-2 |
Function | Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:19349578, ECO:0000269|PubMed:32127020}. Cytoplasm Note=Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor. |
Tissue Location | Expressed in the cochlea (at protein level) (PubMed:32127020). Expressed in the brain and retina (PubMed:15863505, PubMed:7590241). A very low level of expression is seen in the stomach and lung (PubMed:15863505, PubMed:7590241). Expressed in the kidney (PubMed:15863505). |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18396-401. 2. J Biol Chem. 2008 Nov 28;283(48):33730-5. 3. Nature. 2008 Oct 23;455(7216):1124-8.
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