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CDH23 / Cadherin 23 Antibody (aa61-110)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, E |
|---|---|
| Primary Accession | Q9H251 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 369kDa |
| Dilution | ELISA (1:10000), IF (1:100-1:500), IHC-P (1:100) |
| Gene ID | 64072 |
|---|---|
| Other Names | Cadherin-23, Otocadherin, CDH23, KIAA1774, KIAA1812 |
| Target/Specificity | CDH23 Antibody detects endogenous levels of total CDH23 protein. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | CDH23 / Cadherin 23 Antibody (aa61-110) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDH23 {ECO:0000303|PubMed:11138009, ECO:0000312|HGNC:HGNC:13733} |
|---|---|
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Particularly strong expression in the retina (PubMed:11138009). Found also in the cochlea |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
References
Bolz H.,et al.Nat. Genet. 27:108-112(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Lagziel A.,et al.Dev. Biol. 280:295-306(2005).
Deloukas P.,et al.Nature 429:375-381(2004).
Nagase T.,et al.DNA Res. 8:85-95(2001).
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