AP3D1 / Adaptin Delta Antibody (aa686-698)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | O14617 |
Reactivity | Human, Chicken |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 130kDa |
Dilution | ELISA (1:5000-1:20000), IHC-P (2.5 µg/ml), WB (1:500-1:2000) |
Gene ID | 8943 |
---|---|
Other Names | AP-3 complex subunit delta-1, AP-3 complex subunit delta, Adaptor-related protein complex 3 subunit delta-1, Delta-adaptin, AP3D1 |
Target/Specificity | aa 686-698 of Human AP3D1. |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | AP3D1 / Adaptin Delta Antibody (aa686-698) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | AP3D1 |
---|---|
Function | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T- cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). |
Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side |
Tissue Location | Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis |
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Background
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
References
Ooi C.E.,et al.EMBO J. 16:4508-4518(1997).
Simpson F.,et al.J. Cell Biol. 137:835-845(1997).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Zhang C.,et al.Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
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